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抑制剂/激活剂

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凋亡与自噬

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Nocodazole 诺考达唑; Oncodazole; R17934

Nocodazole (Oncodazole) 是快速可逆的 microtubule 抑制剂。 Nocodazole与β-微管蛋白结合并破坏微管组装/拆卸动力学，从而防止有丝分裂并诱导肿瘤细胞凋亡。Nocodazole 抑制 Bcr-Abl，增强 CRISPR/Cas9 的活性。

货号：
TK0237
规格：

5mg

10mg

50mg

100mg
价格：
￥0.00

产品参数

CAS No.	31430-18-9
生物活性	Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl, and activates CRISPR/Cas9.
分子式	C14H11N3O3S
分子量	301.32
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : 20 mg/mL (66.37 mM; Need ultrasonic)
体内研究	Nocodazole (5 mg/kg/three times per week, i.p.) has antitumor effects in athymic mice bearing COLO 205 tumor xenografts. Nocodazole (1 nM) + R-41400 dramatically increase the levels of p21/CIP1 and p27/KIP1 protein in the tumor tissues.
体外研究	Nocodazole exhibits good affinity toward c-KIT, with a Kd value of 1.6 μM in highly malignant human cancer cells. Nocodazole displays good binding affinity toward the components of the mitogen-activated protein kinase (MAPK) pathway, such as BRAF (Kd=1.8 μM), BRAF(V600E) (Kd=1.1 μM), MEK1 (Kd=1.7 μM), and MEK2 (Kd=1.6 μM). Nocodazole has the highest affinity for αβIV and the lowest affinity for αβIII. Nocodazole (1 nM) induces apoptosis of COLO 205 cancer cells. Nocodazole (≥ 30 µg/mL) significantly increases the percentage of annexin-V-binding cells without significantly modifying average forward scatter of human erythrocytes.
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纯度及产品资料	98%

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